Officials will also tout the drug leucovorin as a potential autism treatment, in what President Donald Trump has billed as a “very important” announcement.
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I’ve got no idea what the alleged evidence for this is, but what I do know is that the people making these announcements are completely untrustworthy.
For all the reasons Tylenol should be pulled from shelves, autism probably isn’t one of them.
I’m very happy I didn’t get diagnosed when I was younger, it’s sad though that I have to make the choice to not get diagnosed to not have to worry as much
Same here. I have never been diagnosed with anything mentally related thankfully.
Weird how the famously autistic Temple Grandin had been alive for 8 years when Tylenol went on the market.
-EDIT-
Also:
https://jamanetwork.com/journals/jama/fullarticle/2817406
Findings In this population-based study, models without sibling controls identified marginally increased risks of autism and attention-deficit/hyperactivity disorder (ADHD) associated with acetaminophen use during pregnancy. However, analyses of matched full sibling pairs found no evidence of increased risk of autism (hazard ratio, 0.98), ADHD (hazard ratio, 0.98), or intellectual disability (hazard ratio, 1.01) associated with acetaminophen use.
Weird how the famously autistic Temple Grandin had been alive for 8 years when Tylenol went on the market.
Acetaminophen has been out since the mid/late 1800’s.
I don’t know the background for the bullshit here, but I really doubt anyone is implying that it is the ONLY cause.
Giving fascists the benefit of the doubt is a stupid move.
That is easily explained. Temple Grandin’s parents were time travelers from the future where Tylenol existed, making Temple also a time traveler as a baby to have a birthdate recorded 8 years prior to Tylenol’s release to the market. /s
This will go away as soon as J&J pays the troll toll. We are in the “and I don’t care who knows it!” stage of the kleptocracy.
J&J spun it off into a company called Kenvue a couple years back, so lots less resources to fight it.
what I do know is that the people making these announcements are completely untrustworthy
You are being overly kind. These people are BATSHIT Crazy.
I’d say they’re moronic evil.
This suggests a whole new kind of D&D alignment chart.
I’d say they’re chaotic evil with 0 INT. I’m not even sure where they put their points.
I’d assume Charisma maybe? Like, I don’t find any of them charismatic in the slightest, but Trump especially seems to have this weird ability to make people follow him unquestioningly while he simultaneously fucks them over right to their face.
Charisma, I guess.
I feel ‘evil’ requires a knowledge that what they is doing is wrong with intent in doing so. I don’t think RFKjr is sane enough to know he is being harmful unfortunately. The administration is filled to the brim with both, people being harmful intentionally and ignorantly.
RFK is a crunchy parenting facebook group that has somehow achieved sentience.
I was saying the other day that the only value I can see in RFK is for study, but as the subject. He’s like one of those 19th century rail workers that accidentally blasts a metal rod through his head with dynamite and keeps living somehow. As far as I can tell he can’t be operating on more than 20% of a functional human brain, but how?
Thank you for sharing! Saving a click: So there was a first, flawed study, which studied the link between Tylenol and autism on the basis of correlation (not causality), and they failed to factor in other underlying reasons why parents who end up having an autistic child might use acetaminophen slightly more often (ex: the parents themselves have a condition that makes them take Tylenol more often). The new thorough study clearly demonstrates that there are no links.
The experiments that proves no connection between Tylenol and autism has been done two ways:
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In the 80s there was a tainted Tylenol scandal and sales were suspended and all pills recalled. Sales dipped to near zero for years. No difference to autism rates.
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Many countries avoid Tylenol use due to liver toxicity. No difference in autism rates.
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Is this butterfly an autism?
Fabulous! Now treat those with autism with respect and dignity…
I think this is a lead up to rounding up everyone with autism and moving them to special camps for “education”.
Knowing the current administration, it’s probably so then can start selling sugar pills that ‘reverse Tylenol autism’ for $2K/pill and use them to loot the healthcare system.
Best I can do is arrest all the parents who gave their kids Tylenol for neglect and put them in camps.
And the kids too. Oh and we can give them all free jobs while they are there to give them the opportunity for them to learn new trades.
These non-human second rate child abusers need to be separated from us, they were attacking the children!
Starting with eliminating these bullshit claims for “causes” of autism.
McNeil Consumer Healthcare must not have paid their bribe money.
Look, acetaminophen is one of the most harmful OTC drug without this nonsese.
If they stop here, fine. But fight it like hell.
Alcohol is worse. Why is no on banning it?
If you take too much of something, it becomes harmful. What an epiphany.
I mean the sheer amount of sugar in our food has to be the largest cost to lifespans/healthcare in the U.S.
Id like to see us make a change over time introducing not bans but better ways to regulate packaging.
I don’t want it to have warnings everywhere and dead fetuses and shit, I just want things like, green boxes, blue boxes, magenta boxes, stuff like that. Maybe an easy to see letter in the lower left for those who are color blind
It’s also worth noting that it’s pretty much the only OTC painkiller you’re allowed to take while pregnant, so
A. I would imagine the percentage of people who’ve taken it at least once while pregnant is staggeringly high, to such a point that this would be very difficult to adequately establish causation and
B. They are, once again, just screwing over pregnant people
Source please? I haven’t been able to find anything credible about whatever danger it is you’re referencing - unless the danger is overdosing because the person didn’t know they were taking acetaminophen in different forms? If the danger is people not bothering to check what they’re ingesting, I’ll concede that’s a clear and ever-present danger - just not one specific to acetaminophen.
I think the reason people overdose on Tylenol, and often don’t realize that’s the problem until their liver is failing, is that for decades Tylenol was presented as the “safe” choice for fever and pain control. Which really just means it’s not going to give little kids Reye Syndrome. But because you’ve absorbed that idea as a little kid, you’re not looking for danger unless you specifically re-learn about overdose hazard. And too many people don’t, because shitty education. Then you add all the mixed “cold and flu” OTC medications with the ingredients in tiny print, and the fact that by the time you have uncomfortable symptoms it’s probably too late to pump your stomach, so people die. And that’s without counting in the little ones who got into the grape chewables or drank the whole bottle of the baby’s bubblegum liquid.
Editing to add: In my experience, Tylenol just doesn’t do a very good job of easing pain, which might also lead to overdose. It never worked for my severe period cramps, which Advil did. And there’s a case of a man dying because he took 5 extra-strength every hour trying to control his dental pain, which I would never do but I can affirm it doesn’t do shit for toothache either.
But autism? Nah.
A combination of ibuprofen and acetaminophen (paracetamol) is a crazy effective painkiller. It’s been found to be even more effective than some opioids. Watch your dosage, know what you’re taking, and it’s perfectly safe.
If you do that, be sure to space them out, alternating, with at least a couple of hours between. Having done it on doctor’s advice, I’ve noticed the Tylenol is barely enough to keep me hanging on as the previous Advil wears off and until I can take the next one. I’m not 💯% sure it was helping at all, but at least I could say to myself, “surely it will be kicking in any moment now…” until I got through to where I could start saying “Only half an hour more until you can take the good stuff.”
I think people have idiosyncratic responses to pain meds. I don’t respond to Aleve either. Aspirin is mildly helpful. But a single Motrin was all I needed the day after a C-section.
Huge risk of liver toxicity. Mix two drugs then drink like an average American and the liver has no chance.
People take 2x doses of ibuprofen to recover from hangover.
Then don’t drink. Why would you mix poison with medicine and think that’s an ok thing to do? No shit that’s bad for you.
If you are taking any kind of medicine, don’t drink. If people are too stupid to realize that, then they are deserving of the Darwin Award.
Also, don’t eat grapefruit when taking medicine. That one is more forgivable because it’s not obvious it’s a problem.
but autism? Nah.
Preaching to the choir haha.
Regarding your point on the efficacy of acetaminophen: agreed wholeheartedly. Like /u/i_has_a_hat said, if you combine it with ibuprofen it’s far more effective. My go-to for bad pain is 500-1000mg acetaminophen and 400mg ibuprofen; I stole the idea from my ex’s neurologist when he prescribed it for dealing with the side effects of her main medication (and he also specifically said it would help with her period cramps too, hers were always bad).
As to the guy taking 5 an hour… That’s an incredible amount of acetaminophen, even “normal strength”. You said you wouldn’t, I think I couldn’t take that many pills. Just the idea has me gagging 🤢 I think it’s fair to call that one an outlier in the data.
My doctors have said to take them alternating, not at the same time, and it has worked to smooth out the waves a bit although I’m definitely aware of the difference in effectiveness.
And yes, that dude must have been crazy, badly misunderstood directions, or just in such agonizing pain he didn’t care he was killing himself. Sadly, liver failure is also a painful way to go.
US consumers have been completely brainwashed into taking drugs for any minor inconvenience and told they are safe. The only truly safe drug is drug that does nothing.
Because they are directly marketed to, they overdose or mix NSAIDs until their kidneys and livers fail.
Yeah, it’s easy to take too much.
https://www.ncbi.nlm.nih.gov/books/NBK441917/
https://emedicine.medscape.com/article/820200-overview
https://www.hopkinsmedicine.org/health/conditions-and-diseases/acute-liver-failure
https://pmc.ncbi.nlm.nih.gov/articles/PMC5962381/
https://www.uspharmacist.com/article/acetaminophen-toxicity-what-pharmacists-need-to-know
You … You didn’t try at all, did you?
I appreciate the sources, but I don’t appreciate the
You… you didn’t try at all, did you?
Because nothing you’ve posted here is news to me. I think you’ll find I said:
If the danger is people not bothering to check what they’re ingesting, I’ll concede that’s a clear and ever-present danger - just not one specific to acetaminophen.
So I’ll just quote directly from your very first link, because the rest of them don’t say anything different:
Responsible for 56,000 emergency department visits and 2600 hospitalizations, acetaminophen poisoning causes 500 deaths annually in the United States. Notably, around 50% of these poisonings are unintentional, often resulting from patients misinterpreting dosing instructions or unknowingly consuming multiple acetaminophen-containing products.
And
At therapeutic levels, acetaminophen is generally considered safe. However, instances of acetaminophen toxicity often arise due to patient misconceptions about dosing or a lack of awareness regarding its presence in multiple medications they may be consuming. Intentional ingestion of large doses also contributes to toxicity.
So, in around 50% of cases, the danger is people not bothering to check what they’re ingesting. They took other medications containing acetaminophen and didn’t know it, or they took other drugs that amplified the ability of the acetaminophen to cause damage (like alcohol, which is made very clear you’re not supposed to take with acetaminophen).
In the rest, overdoses were intentionally taken, so you can’t really count those in the danger statistics since the goal was to use it dangerously.
To put this in perspective:
When taken at therapeutic doses, acetaminophen has a good safety profile. The therapeutic doses are:
- 10 to 15 mg/kg/dose in children every 4 to 6 hours with a maximum dose of 80 mg/kg/d
- 325 to 1000 mg/dose in adults every 4 to 6 hours, with a maximum daily dose of 4 g/d
Toxicity is likely to develop in adults at:
- >12 g over a 24 hours
- 7.5 to 10 g in a single dose
- Doses >350mg/kg
Toxicity in children occurs following a single dose of 150 mg/kg or 200 mg/kg in otherwise healthy children aged 1 to 6.
Just do the maths on how much acetaminophen you normally take for any given ailment, and you’ll realise just how far beyond those doses the danger really lies (or maybe that you’re one of the people who doesn’t check what they’re taking).
So, to conclude: acetaminophen is indeed dangerous if you don’t pay attention to what you’re taking or how much. Other examples of things that are dangerous if you don’t use them right: cars, ovens, lawnmowers, cotton buds, the internet… the full list is quite long, actually, but I’m sure you get the idea.
Lol who downvoted this
I’ll give you one guess :P
What a tool.
Many countries discourage these drugs. Switzerland and Germany, most of EU.
It sounds like the health care sector in the EU generally is worried about the misuse of acetaminophen, like for a “Paracetamol Challenge” on the level of the “Tide Pod Challenge”: https://www.euractiv.com/section/health-consumers/news/what-is-the-paracetamol-challenge-that-has-europe-nervous/
The misuse of any OTC drug is worrying, but this doesn’t translate into a general discouragement, and certainly not because of the “danger” that some people might not take it as directed.
The dosage they describe as overdosing in adults is 24x that of a high strength recommended dosage. That does not seem “easy” to OD.
I think the point is that it can cause serious damage/death if you take too much… Which is maybe a bit unique among OTC medications specifically
Yeah no. Aspirin is lethal at much lower doses.
Nobody said acetaminophen is the only one like it, just that it’s not common
Which is maybe a bit unique among OTC medications specifically
- spongebue
“a bit”
But I suppose I was listening to something on NPR a few months ago where someone complained about describing things with varying degrees of uniqueness (eg, “a bit”) because unique is technically a binary descriptor. Something I learned in that moment and apparently forgot soon after.
My ex’s cousin died from renal failure from Tylenol.
All painkillers have downsides. Ibuprofen triples the risk of stroke—more with greater dosages. But claiming Tylenol causes autism is stupid.
Tylenol is not nephrotoxic. It’s metabolized by the liver, and it can absolutely cause damage in high doses, but I think your statement is in error.
Conclusion
Acetaminophen is associated with a significantly increased risk of newly developing renal impairment in adults. Physicians who prescribe acetaminophen should be aware of potential adverse renal effects. A longitudinal study that further explores this association is warranted.
I’m calling bullshit on this claim
