1: Old motherboard PCI-E generation slot may bottleneck bandwidth, make sure you use the slot closet to the CPU for 16x speeds.
2: Old CPU might get bogged down by the massive modern video drivers and make the GPU under perform.
3: Going forward you’ll need to consider ReBar support. The newest Radeon GPU will under perform without ReBar enabled. If you don’t have that feature, it’ll still work, but look up on/off benchmarks.
4: Make sure your power supply can handle any upgrades.
Yes*
1: Old motherboard PCI-E generation slot may bottleneck bandwidth, make sure you use the slot closet to the CPU for 16x speeds.
2: Old CPU might get bogged down by the massive modern video drivers and make the GPU under perform.
3: Going forward you’ll need to consider ReBar support. The newest Radeon GPU will under perform without ReBar enabled. If you don’t have that feature, it’ll still work, but look up on/off benchmarks.
4: Make sure your power supply can handle any upgrades.